For centuries, many secret organizations have taken part in exterminating various types of dangerous monsters. One of them is the England-based Hellsing, run by its cunning leader, Sir Integra Fairbrook Wingates Hellsing. Her greatest hunter, and trump card, is Alucard, an unbeatable vampire genetically modified by her father. Despite him being one of "them," he swore to be her protector and servant.

A new crisis begins and with the help of Seras Victoria, his recently turned vampire partner, Alucard has to uncover the truth behind the mysterious vampire attacks. Not every human is bound to be his ally in this battle, and he will not hesitate to kill anyone who stands in his way.