Nadeko Sengoku is an average, carefree middle school student. On the road to school one day, she runs into Ran Hokkyokusei, who she soon finds out is a new transfer student. When Ran tries to flirt with Nadeko, he is intercepted by Sui, her childhood friend, who claims that Nadeko belongs to him.

Kimi to Nadekko! revolves around Nadeko and the two boys as their rivalry and determination to make Nadeko’s heart sway toward them intensifies.