Fukamachi Sho and Segawa Tetsurou are ordinary high schoolers and best friends. One day, they witness an explosion at a nearby mountain and go investigate. There, Sho finds a strange artifact that physically bonds with him! It’s the beginning of him being the new user of the alien suit called Guyver!

However, there is an organization called Chronos that will go through any lengths to take that suit of armor. They create monsters known as Zoanoids to attack him and those he loves in order to steal Guyver -- but Sho isn’t going down without a fight!