Usami-san to Kamei-kun" is a story about Usami, a high school girl who values rationality and efficiency, and Kamei-kun, the son of an actor who likes to do things at his own pace. Usami, a rather rash person when it comes to most things, fell in love at first sight with the childhood friend of Kamei, Takeshi. She goes right ahead and voices her feelings to him, thinking, "Rather than dawdling around, it's more efficient to confess!" Seeing that, Kamei warns her, "That will only be troublesome to him.